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Decaschistia intermedia Craib 추출물의 멜라닌 합성 억제 효능

Inhibitory Effects of Decaschistia intermedia Craib Extract on Melanin Synthesis

생약학회지 2020년 51권 3호 p.171 ~ 177
임리진, 추병삼, 이상우, Douangdeuane Bounleuane, 송희상,
소속 상세정보
임리진 ( Lim Lee-Jin ) - Chosun University Cancer Mutation Research Center
추병삼 ( Chu Byeong-Sam ) - Chosun University Graduate School Department of Biomedical Sciences
이상우 ( Lee Sang-Woo ) - Korea Research Institute of Bioscience and Biotechnology International Biological Material Research Center
 ( Douangdeuane Bounleuane ) - Lao Ministry of Health Institute of traditional medicine
송희상 ( Song Hee-Sang ) - Chosun University Graduate School Department of Biomedical Sciences

Abstract


The purpose of this study was to investigate the anti-melanogenic effects of the extracts from Decaschistia intermedia craib (EDI). In this study, we examined the effects of EDI on mushroom tyrosinase activity in in vitro, melanin contents, and expression levels of mRNA and proteins of melanogenesis-related genes in B16F10 melanoma cells. The treatment of EDI significantly decreased both tyrosinase activity and melanin contents in B16F10 cells with dose-dependent manner. In addition, we found that the expression of mRNA or proteins of melanogenic proteins, such as, a-melanocyte-stimulating hormone (a-MSH)-induced microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1), and TRP-2 was significantly downregulated with dose-dependent manner in the EDI-treated B16F10 cells compared to controls. Our results suggest that the EDI inhibits cellular melanogenesis through downregulation of a-MSH-stimulated melanin synthesis. Thus EDI may potentially be an effective whitening agent.

키워드

Decaschistia intermedia craib; Melanin synthesis; Tyrosinase activity

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