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엉겅퀴, 울금, 개똥쑥 복합 추출물의 지방간 개선효과

Ameliorative Effects of Cirsium jaonicum, Artemisia annua and Curcuma longa on Non-alcoholic Fatty Liver Disease

생약학회지 2020년 51권 3호 p.178 ~ 185
신재영, 강현주, 조병옥, 박지현, 데니스, 학소평, 왕봉, 심재석, 심동준, 장선일,
소속 상세정보
신재영 ( Shin Jae-Young ) - Jeonju University Institute of Health Science
강현주 ( Kang Hyun-Ju ) - Jeonju University Institute of Health Science
조병옥 ( Cho Byoung-Ok ) - Jeonju University Institute of Health Science
박지현 ( Park Ji-Hyeon ) - Jeonju University Institute of Health Science
데니스 ( Denis Nchang Che ) - Jeonju University Institute of Health Science
학소평 ( Hao Suping ) - Jeonju University Institute of Health Science
왕봉 ( Wang Feng ) - Jeonju University Institute of Health Science
심재석 ( Sim Jae-Suk ) - Imsil Herbal Medicine Association Research Institute
심동준 ( Sim Dong-Jun ) - Imsil Herbal Medicine Association Research Institute
장선일 ( Jang Seon-Il ) - Jeonju University Department of Health Management

Abstract


In this study, the effect of complex hot water extracts of Cirsium jaonicum, Artemisia annua and Curcuma longa (CAC) on the improvement of non-alcoholic fatty liver disease (NAFLD) was investigated. CAC inhibited fatty acid synthesis and lipid accumulation in HepG2 cells cultured with free fatty acid (FFA). In the NAFLD animal model, CAC extract suppressed the increase in body weight, liver, and epididymis fat weight, and suppressed the increase in hepatocyte fat and blood triglyceride. In addition, by blocking the Nrf2/HO-1 signaling pathway, cells were protected from oxidative stress in hepatocytes. Moreover, CAC inhibited the expression of COX-2, iNOS, TNF-a and IL-17 in hepatocytes. These results suggest the possibility that CAC extract can be applied in the field of health functional foods and pharmaceuticals for improvement and prevention of NAFLD.

키워드

Cirsium jaonicum; Artemisia annua; Curcuma longa; Non-alcoholic fatty liver disease; IL-17

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