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팥배나무의 진통 효과

Anti-nociceptive Effects of Sorbus alnifolia

생약학회지 2020년 51권 3호 p.186 ~ 191
김봉석, 윤선화, 신윤철, 강보혜, 박승주, 양우인, 이세연, 차동석, Jeon Hoon,
소속 상세정보
김봉석 ( Kim Bong-Seok ) - Woosuk University College of Pharmacy
윤선화 ( Yun Sun-Hwa ) - Woosuk University College of Pharmacy
신윤철 ( Shin Youn-Chel ) - Woosuk University College of Pharmacy
강보혜 ( Kang Bo-Hye ) - Woosuk University College of Pharmacy
박승주 ( Park Seung-Ju ) - Woosuk University College of Pharmacy
양우인 ( Yang Woo-In ) - Woosuk University College of Pharmacy
이세연 ( Lee Se-Youn ) - Woosuk University College of Pharmacy
차동석 ( Cha Dong-Seok ) - Woosuk University College of Pharmacy
 ( Jeon Hoon ) - Woosuk University College of Pharmacy

Abstract


In this study, we evaluated the anti-nociceptive activities of Sorbus alnifolia. To investigate the anti-nociceptive properties of the methanolic extract of Sorbus alnifolia (MSA), we conducted several tests using various experimental mouse pain models. Herein, MSA significantly delayed the latency time and writhing motion in the hotplate test and acetic acid test, respectively. These result indicated that MSA has an ability to manage both peripheral and central nociception. We could further confirm the analgesic effects of MSA by performing formalin test. In combination test using naloxone, a non-selective opioid receptor antagonist, analgesic activity of MSA was partly antagonized by naloxone, but not completely, indicating that the MSA acts as a partial opioid receptor agonist. Out results suggest that the S. alnifolia may be possibly used as valuable anti-nociceptive agent.

키워드

Sorbus alnifolia; Anti-nociception; Opioid receptor

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