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비트 Methanol 추출물의 예쁜 꼬마선충에 대한 항산화 효과

Antioxidant Activity of Beta vulgaris L. Methanol Extract in Caenorhabditis elegans

생약학회지 2020년 51권 3호 p.192 ~ 198
김준형, 권강무, 이은서, 김대근, 박정숙, 이재혁,
소속 상세정보
김준형 ( Kim Jun-Hyeong ) - Woosuk University Department of Food Science and Biotechnology
권강무 ( Kwon Kang-Mu ) - Woosuk University Department of Pharmacy
이은서 ( Lee Eun-Seo ) - Nambu University Department of Oriental Pharmaceutical Development
김대근 ( Kim Dae-Keun ) - Woosuk University Department of Pharmacy
박정숙 ( Park Jeong-Sook ) - Nambu University Department of Nursing
이재혁 ( Lee Jae-Hyeok ) - Nambu University Department of Emergency Medical Rescue

Abstract


Caenorhabditis elegans model system was used to investigate the antioxidant activity of Beta vulgaris L. (Chenopodiaceae) methanol extract. The methanol extract showed DPPH radical scavenging and superoxide quenching activity in a dose-dependent manner. The B. vulgaris methanol extract was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans, along with reactive oxygen species (ROS) level. In addition, to see that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the methanol extract, SOD-3 expression was measured using a transgenic strain. As a result, the B. vulgaris methanol extract increased SOD and catalase activities, and decreased ROS accumulation, dose-dependently. Furthermore, the methanol extract-treated CF1553 worm showed higher SOD-3::GFP intensity than the control.

키워드

Beta vulgaris L.; Caenorhabditis elegans; Antioxidant; Catalase; ROS

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