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모과의 추출조건에 따른 Protocatechuic Acid 함량 변화 및 활성 평가

Protocatechuic Acid Content and Physiological Activities of Chaenomeles sinensis Extracts Prepared with Different Methods

생약학회지 2020년 51권 3호 p.199 ~ 206
이정호, 임소연, 이왕로,
소속 상세정보
이정호 ( Lee Jeong-Ho ) - Sunchang Research Institute of Health and Longevity
임소연 ( Im So-Yeon ) - Sunchang Research Institute of Health and Longevity
이왕로 ( Lee Wang-Ro ) - Jeonbuk National University Faculty of Liberal Education

Abstract


The aim of this study was to investigate the potential of Chaenomeles sinensis as a content of protocatechuic acid and physiological activities. The analyzed the content of protocatechuic acid of Chaenomeles sinensis water extract (CSW) according to different extract temperature and time for extraction. It was analyzed as 0.14±0.00 mg/g in the extract at 100oC for 3 h. Protocatechuic acid content increased as extraction time and temperature increased. The activity of the CSW at 100oC for 3 h was measured. As a result of measuring DPPH, ABTS radical scavenging activity and SOD activity, antioxidant activity was found and a-glucosidase inhibition activities. Cell viability was shown for RAW 264.7 cells, and NO (nitric oxide) production was also inhibited. Finally, content of protocatechuic acid increased with increasing extraction time and extraction temperature, and exhibited antioxidant activity, inhibition of NO production, and anti-diabetic activity. It is believed that the Chaenomeles sinensis is likely to be developed as a functional material.

키워드

Chaenomeles sinensis; Protocatechuic acid; Antioxidant; α-Glucosidase; Nitric oxide

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