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Simultaneous Quantitative Analysis of Mixtures of Ixeridium dentatum (Thunb.) Tzvelev, Plantago asiatica L. and Rumex crispus L. Ethanol Extracts

생약학회지 2020년 51권 3호 p.222 ~ 229
김가람, 김은남, 비라수렌 바야르마, 민연홍, 정길생,
소속 상세정보
김가람 ( Kim Ga-Ram ) - Keimyung University College of Pharmacy
김은남 ( Kim Eun-Nam ) - Keimyung University College of Pharmacy
비라수렌 바야르마 ( Birasuren Bayarmaa ) - Topworld
민연홍 ( Min Yeon-Hong ) - Topworld
정길생 ( Jeong Gil-Saeng ) - Keimyung University College of Pharmacy

Abstract


Recently, consume for functional cosmetics containing natural products has been greatly increased. In order to develop it as a natural cosmetic material, we selected Ixeridium dentatum (Thunb.) Tzvelev, Plantago asiatica L. and Rumex crispus L. that have antioxidant and anti-inflammatory effects. In this study, simultaneous quantitative analysis of the isolated compounds and natural product complexes (Mix.) were validated using high performance liquid chromatography (HPLC). The isolated six compounds were shown in a large linearity with a correlation coefficient (R2) of 0.99. The limit of detection (LOD) of chlorogenic acid, plantamajoside, acteoside, emodin chrysophanol and physcion were 0.36 μg/mL, 0.36 μg/mL, 0.37 μg/mL, 0.30 μg/mL, 0.22 μg/mL and 0.12 μg/mL, respectively. The limit of quantification (LOQ) of chlorogenic acid, plantamajoside, acteoside, emodin chrysophanol and physcion were 1.10 μg/mL, 1.08 μg/mL, 1.12 μg/mL, 0.99 μg/mL, 0.66 μg/mL and 0.35 μg/mL, respectively. Content analysis showed chlorogenic acid (0.19 ± 0.02%), plantamajoside (0.48 ± 0.01%), acteoside (0.65 ± 0.01%), emodin (1.15 ± 0.11%), chrysophanol (0.73 ± 0.01%) and physcion (0.69 ± 0.09%). Therefore, the results of this study may provide for basic data of standardization research natural cosmetic material development on the I. dentatum, P. asiatica and R. cripus.

키워드

HPLC; Quantitative; Ixeridium dentatum (Thunb.) Tzvelev; Plantago asiatica L.; Rumex crispus L.

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