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Global Regulators to Activate Silent Biosynthetic Gene Clusters

Natural Product Sciences 2020년 26권 3호 p.183 ~ 190
심상희,
소속 상세정보
심상희 ( Shim Sang-Hee ) - Duksung Women’s University College of Pharmacy

Abstract


Genome mining has recently emerged as a powerful strategy to discover novel microbial secondary metabolites. However, more than 50% of biosynthetic gene clusters are not transcribed under standardized laboratory culture condition. Several methods have been applied to activate silent biosynthetic gene clusters in the microbes so far. Among the regulatory systems for production of secondary metabolites, global regulators, which affect transcription of genes through regulatory cascades, typically govern the production of small molecules. In this review, global regulators to affect production of microbial secondary metabolites were discussed.

키워드

Microbial natural products; Secondary metabolites; Biosynthetic gene clusters; Global regulators

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