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Protective Effect of Rice Bran Oil against β-Amyloid Protein-Induced Memory Impairment and Neuronal Death in Mice

Natural Product Sciences 2020년 26권 3호 p.221 ~ 229
장지연, 이홍규, Yoo Hwan-Su, 성연희,
소속 상세정보
장지연 ( Jang Ji-Yeon ) - Chungbuk National University College of Veterinary Medicine
이홍규 ( Lee Hong-Kyu ) - Chungbuk National University College of Veterinary Medicine
 ( Yoo Hwan-Su ) - Chungbuk National University College of Pharmacy
성연희 ( Seong Yeon-Hee ) - Chungbuk National University College of Veterinary Medicine

Abstract


This study was undertaken to investigate the protective effect of rice bran oil (RBO) on amyloid β protein (Aβ) (25-35)-induced memory impairment and brain damage in an ICR mouse model. Memory impairment was produced by intracerebroventricular microinjection of 15 nmol Aβ (25-35) and assessed using the passive avoidance test. Treatment with RBO at 0.1, 0.5, or 1 mL/kg (p.o. daily for 8 days) protected against Aβ (25-35)-induced memory impairment. Furthermore, Aβ (25-35)-induced decreases in glutathione and increases in lipid peroxidation and cholinesterase activity in brain tissue were inhibited by RBO, and Aβ (25-35)- induced increases of phosphorylated mitogen-activated protein kinases (MAPKs) and inflammatory factors, and changes in the levels of apoptosis-related proteins were significantly inhibited by RBO. Furthermore, Aβ (25-35) suppressed the PI3K/Akt pathway and the phosphorylation of CREB, but increased phosphorylation of tau (ptau) in mice brain; these effects were significantly inhibited by administration of RBO. These results suggest that RBO inhibits Aβ (25-35)-induced memory impairment by inducing anti-apoptotic and anti-inflammatory effects, promoting PI3K/Akt/CREB signaling, and thus, inhibiting p-tau formation.

키워드

rice bran oil; Alzheimer's disease; amyloid β protein; 25-35; memory impairment; neuroprotection

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