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Liver Function Analyses and Spleen Histology Assessment Following the Co-administration of Cisplatin and Methanolic Extract of Portulaca Oleracea in Wistar Rats: An Experimental Study

Natural Product Sciences 2020년 26권 3호 p.252 ~ 258
Okafor Izuchukwu Azuka, Nnamah Uchenna Somtochukwu, Nnaka Jude,
소속 상세정보
 ( Okafor Izuchukwu Azuka ) - Nnamdi Azikiwe University Faculty of Basic Medical Sciences Department of Anatomy
 ( Nnamah Uchenna Somtochukwu ) - Babcock University Teaching Hospital Hematology Department
 ( Nnaka Jude ) - Nnamdi Azikiwe University Faculty of Basic Medical Sciences Department of Anatomy

Abstract


This study investigated the biochemical and histological changes associated with the co-administration of cisplatin and methanolic extract of Portulaca oleracea (MEPO) in adult Wistar rats. Twenty-four (24) adult female Wistar rats were randomly divided into six (6) groups (A-F) (n = 4). Group A served as the control group for the experiment and received no treatment. Group B was given a single dose of cisplatin and served as the cisplatin control group. Group C and D received 400 mg/kg and 800 mg/kg of MEPO 6 hours after a single dose cisplatin injection respectively. Group E and F received 400 mg/kg and 800 mg/kg of MEPO 6 hours before cisplatin injection. The cisplatin injection was 2 mL/kg given intraperitoneally for all groups. There was a significant increase in the serum levels of ALT, ALP, AST, total bilirubin, and conjugated bilirubin following cisplatin treatment (p = 0.000, 0.000, 0.039, 0.000, 0.004 respectively) with a consequent reversal due to MEPO administration across all treated groups (p = 0.000, 0.000, 0.000, and 0.000) in a dose-dependent fashion. Cisplatin caused the expansion of the red and white pulp in the spleen which was attenuated by MEPO. MEPO demonstrated a protective effect against cisplatin-induced liver and spleen toxicity.

키워드

Portulaca oleracea; liver function test; cisplatin; spleen; histology; toxicity

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