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Extracellular matrixes and neuroinflammation

BMB Reports 2020년 53권 10호 p.491 ~ 499
장동길, 심효정, 송은경, 권태준, 박태주,
소속 상세정보
장동길 ( Jang Dong-Gil ) - Ulsan National Institute of Science and Technology School of Life Sciences
심효정 ( Sim Hyo-Jung ) - Ulsan National Institute of Science and Technology School of Life Sciences
송은경 ( Song Eun-Kyung ) - Ulsan National Institute of Science and Technology School of Life Sciences
권태준 ( Kwon Tae-Joon ) - Ulsan National Institute of Science and Technology School of Life Sciences
박태주 ( Park Tae-Joo ) - Ulsan National Institute of Science and Technology School of Life Sciences

Abstract


The extracellular matrix is a critical component of every human tissue. ECM not only functions as a structural component but also regulates a variety of cellular processes such as cell migration, differentiation, proliferation, and cell death. In addition, current studies suggest that ECM is critical for the pathophysiology of various human diseases. ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid. Each component of ECM exerts its own functions in cellular and pathophysiological processes. One of the interesting recent findings is that ECM is involved in inflammatory responses in various human tissues. In this review, we summarized the known functions of ECM in neuroinflammation after acute injury and chronic inflammatory diseases of the central nerve systems.

키워드

DAMP; Extracellular matrix; Neurodegenerative disease and ECM; Neuroinflammation; Neuronal ECM

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