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ROLE OF PREFRONTAL CORTICAL NMDA NR2B SUBTYPE RECEPTOR IN FEAR- AND WORKING-MEMORY

Korean Journal of Physiology & Pharmacology 2006년 10권 0호 p.66 ~ 0
Li Baoming,
소속 상세정보
 ( Li Baoming ) - Fudan University Institute of Neurobiology

Abstract


Glutamate NMDA receptor (NMDA-R) is required for synaptic plasticity. NMDA-R is composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits. The formation of a functional NMDA-R requires a combination of NR1, an essential channel-forming subunit, and at least one NR2 subunit. Both NR2A- and NR2B-dependent signaling pathways are involved in long-term synaptic plasticity in the central nervous system. The anterior cingulate cortex (ACC), a part of the prefrontal cortex, is thought to be important for emotional memory, and the medial prefrontal cortex (mPFC), a cortical area anterior to the ACC, is essential for working memory. However, little is known about the functional roles of NR2A and NR2B subunits in the ACC and mPFC in memory functions. In the present study, we provide strong evidence that both NR2A and NR2B subunits in the ACC contribute to the formation of classical contextual fear memory, and NR2B in the mPFC to the behavioral expression and neural representation of working memory.

Source: Korean J Physiol Pharmacol.2006 Oct;10(Suppl II):105

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