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Practical considerations for the study of the oral microbiome

International Journal of Oral Biology 2020년 45권 3호 p.77 ~ 83
유연이, 이서영, 나희삼,
소속 상세정보
유연이 ( Yu Yeun-I ) - Pusan National University Interdisplinary Program of Genomic Science
이서영 ( Lee Seo-Young ) - Pusan National University Interdisplinary Program of Genomic Science
나희삼 ( Na Hee-Sam ) - Pusan National University School of Dentistry Department of Oral Microbiology

Abstract


In the oral cavity, complex microbial community is shaped by various host and environmental factors. Extensive literature describing the oral microbiome in the context of oral health and disease is available. Advances in DNA sequencing technologies and data analysis have drastically improved the analysis of the oral microbiome. For microbiome study, bacterial 16S ribosomal RNA gene amplification and sequencing is often employed owing to the cost-effective and fast nature of the method. In this review, practical considerations for performing a microbiome study, including experimental design, molecular analysis technology, and general data analysis, will be discussed.

키워드

Oral microbiome; 16S rDNA; Bacterial associations; High-throughput nucleotide sequencing

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