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기억상실형 경도인지장애와 알츠하이머 치매에서의 수면과 C-반응단백질의 연관성

Correlation between Sleep and C-reactive Protein of Patients in Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia

노인정신의학 2020년 24권 2호 p.69 ~ 74
김하연, 홍승철, 정종현, 서호준, 김태원, 김성민, 오지혜, 정준수, 엄유현,
소속 상세정보
김하연 ( Kim Ha-Yeon ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
홍승철 ( Hong Seung-Chul ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
정종현 ( Jeong Jong-Hyun ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
서호준 ( Seo Ho-Jun ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
김태원 ( Kim Tae-Won ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
김성민 ( Kim Sung-Min ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
오지혜 ( Oh Ji-Hye ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
정준수 ( Chung Jun-Soo ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
엄유현 ( Um Yoo-Hyun ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry

Abstract


Objective: Sleep affects systemic inflammation and amyloid deposition, and sleep disturbance is known to be a risk factor for cognitive decline. To date, literatures on the relationship between peripheral inflammatory markers and sleep in Alzheimer’s dementia and mild cognitive impairment patients have been scarce. The aim of this study was to determine the correlation between sleep and C-reactive protein (CRP) in Alzheimer’s dementia and amnestic mild cognitive impairment patients.

Methods: A total of 81 patients were divided in to four groups: amyloid negative healthy control, amyloid negative amnestic mild cognitive impairment, amyloid positive amnestic mild cognitive impairment, and amyloid positive Alzheimer’s dementia.
Demographic data and cognitive measurement through the Consortium to Establish a Registry for Alzheimer’s Disease were conducted. Amyloid positivity status was attained through positron emission tomography scans using [18F]-flutemetamol. The quality of sleep was evaluated by the sleep item of Korean Neuropsychiatric Inventory (K-NPI-SLEEP), and peripheral blood tests were conducted to measure CRP.

Results: There was no statistically difference in CRP levels or K-NPI-SLEEP scores among four groups. Moreover, there was no association between K-NPI-SLEEP and CRP in four groups.

Conclusion: Since K-NPI-SLEEP score shows overall, subjective sleep problems, further follow-up studies in consideration for objective sleep studies to unravel the relationship of peripheral inflammatory markers and sleep in amnestic mild cognitive impairment and Alzheimer’s dementia patients.

키워드

Sleep; C-reactive protein; Alzheimer disease; Amyloid; Inflammation

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