잠시만 기다려 주세요. 로딩중입니다.

Histological Analysis of Reproductive System in Low-Dose Nonylphenoltreated F1 Female Mice

발생과생식 2020년 24권 3호 p.159 ~ 165
김용빈, 전용필, 최돈찬, 이성호,
소속 상세정보
김용빈 ( Kim Yong-Bin ) - Sangmyung University Department of Biotechnology
전용필 ( Cheon Yong-Pil ) - Sungshin University School of Biosciences and Chemistry Division of Developmental Biology and Physiology
최돈찬 ( Choi Don-Chan ) - Yongin University College of Environmental Sciences Department of Life Science
이성호 ( Lee Sung-Ho ) - Sangmyung University Department of Biotechnology

Abstract


Previously, we reported adverse effects of low-dose nonylphenol (NP) exposure on the reproductive parameters of F1 female mice. In the present study we further investigated the pathohistological effect of NP exposure on the reproductive organs in F1 female mice. NP exposures were continuously conducted from parental pre-mating period until the postnatal day (PND) 33 of F1 offspring for vaginal examination. Mice were sacrificed on PND 30 and the reproductive tissue weights were measured. The initial (at PND 21) body weights of the NP-50 group animals were significantly lower than those of control group animals, and the weight deficit were recovered when the terminal (PND 33) body weights were measured.
Early vaginal opening was found in NP group animals (p<0.05). Pathohistological studies revealed that NP-treated F1 animals showed prominent increase in the ovarian follicle numbers (p<0.01), and decrease in the diameter of uterine myometrium (p<0.01), and increase in the diameter of luminal epithelium (p<0.05). The present study demonstrated that the subchronic low-dose NP exposure induced early beginning of puberty and pathohistological abnormalities in ovary and uterus of F1 mice. Further studies are needed to achieve a better understanding on the action mechanism of NP in pubertal onset and to find a way to avoid a hazardous situation provoked by NP exposure.

키워드

Nonylphenol; F1 female mice; Ovary; Uterus; Histology

원문 및 링크아웃 정보

등재저널 정보