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Expression Analysis of the Caspase10 from Olive Flounder (Paralichthys olivaceus) against Viral Hemorrhagic Septicemia Virus (VHSV) Challeng

발생과생식 2020년 24권 3호 p.187 ~ 196
김경희, 이상현, 정효선, 김주란, 박종원, 박철지, 김혜진, 김우진, 이다인,
소속 상세정보
김경희 ( Kim Kyung-Hee ) - National Institute of Fisheries Science Genetics and Breeding Research Center
이상현 ( Lee Sang-Hyun ) - National Institute of Fisheries Science Genetics and Breeding Research Center
정효선 ( Jung Hyo-Sun ) - National Institute of Fisheries Science Genetics and Breeding Research Center
김주란 ( Kim Ju-Lan ) - National Institute of Fisheries Science Genetics and Breeding Research Center
박종원 ( Park Jong-Won ) - National Institute of Fisheries Science Genetics and Breeding Research Center
박철지 ( Park Choul-Ji ) - National Institute of Fisheries Science Genetics and Breeding Research Center
김혜진 ( Kim Hye-Jin ) - National Institute of Fisheries Science Genetics and Breeding Research Center
김우진 ( Kim Woo-Jin ) - National Institute of Fisheries Science Genetics and Breeding Research Center
이다인 ( Lee Da-In ) - National Institute of Fisheries Science Genetics and Breeding Research Center

Abstract


The caspase10 encodes an initiating caspase that plays an important role in the maintaining the cellular homeostasis by regulating the steps involved in the immune response and cell death. We investigated the expression of caspase10 during the different developmental stages and in olive flounder tissues. Caspase10 increased in the late stage of the formation of immune tissue, and high expression was observed in the gills, kidney, skin, and spleen.
The current study analyzed the expressional changes of caspase10 in olive flounder infected with viral hemorrhagic septicemia virus (VHSV). One of the major causes of mass mortality, VHSV infection in olive flounder attributes to significant expression of caspase10 in the gills, spleen, skin, and kidneys. The results indicate a close association of caspase10 expression with the immune response to VHSV infection in olive flounder. The observations could form the basis data for exploration of other fish immune system.

키워드

Olive flounder Paralichthys olivaceus; Gene expression; Caspase10; Viral hemorrhagic septicemia virus (VHSV)

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