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Altered Gene Expression Profiles in the Lungs of Streptozotocin-induced Diabetic Mice

발생과생식 2020년 24권 3호 p.197 ~ 205
김정현, Rasaei Roya, 박수진, 김지영, 나성훈, 홍석호,
소속 상세정보
김정현 ( Kim Jung-Hyun ) - Kangwon National University School of Medicine Department of Internal Medicine
 ( Rasaei Roya ) - Kangwon National University School of Medicine Department of Internal Medicine
박수진 ( Park Su-Jin ) - Kangwon National University School of Medicine Department of Internal Medicine
김지영 ( Kim Ji-Young ) - Kangwon National University School of Medicine Department of Internal Medicine
나성훈 ( Na Sung-Hun ) - Kangwon National University School of Medicine Department of Obstetrics and Gynecology
홍석호 ( Hong Seok-Ho ) - Kangwon National University School of Medicine Department of Internal Medicine

Abstract


Diabetes mellitus is a common heterogeneous metabolic disorder, characterized by deposition of extracellular matrix, oxidative stress, and vascular dysfunction, thereby leading to gradual loss of function in multiple organs. However, little attention has been paid to gene expression changes in the lung under hyperglycemic conditions. In this study, we found that diabetes inuced histological changes in the lung of streptozotocin-induced diabetic mice.
Global gene expression profiling revealed a set of genes that are up- and down-regulated in the lung of diabetic mice. Among these, expression of Amigo2, Adrb2, and Zbtb16 were confirmed at the transcript level to correlate significantly with hyperglycemia in the lung. We further evaluated the effect of human umbilical cord-derived perivascular stem cells (PVCs) on these gene expression in the lung of diabetic mice. Our results show that administration of PVC-conditioned medium significantly suppressed Amig2, Adrb2, and Zbtb16 upregulation in these mice, suggesting that these genes may be useful indicators of lung injury during hyperglycemia. Furthermore, PVCs offer a promising alternative cell therapy for treating diabetic complications via regulation of gene expression.

키워드

Diabetes; Perivascular cells; Lung; Gene expression profile

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