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Organoids as a New In Vitro Model of Human Norovirus Infection

Journal of Bacteriology and Virology 2020년 50권 3호 p.168 ~ 174
김제형, 정영일,
소속 상세정보
김제형 ( Kim Je-Hyoung ) - Korea National Institute of Health Center for Infectious Disease Research Division of Viral Disease Research
정영일 ( Jeong Young-Il ) - Korea National Institute of Health Center for Infectious Disease Research Division of Viral Disease Research

Abstract


Human noroviruses (HuNoVs) are the main causative viral agents in epidemic and endemic acute gastroenteritis worldwide. Despite their impact on the global economic and health burden, developing effective control measures to prevent and treat norovirus gastroenteritis remains a difficult problem to solve. One of the major reasons for this problem is the lack of affordable small animal models and a robust and reproducible in vitro cell culture system for the propagation of this poorly characterized RNA virus. Recently, the development of a 3-dimensional culture system using pluripotent stem cells to mimic the native small intestine has led to the discovery of new strategies for the cultivation of this virus. In this review, we describe a human stem cell-derived intestinal organoid model that led to the development of the currently available HuNoV in vitro culture systems that support replication of the virus, and provide helpful insights into HuNoV biology and vaccine and therapeutic development.

키워드

Human noroviruses; Human intestinal enteroids; Human intestinal organoids

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