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Recent Research and Knowledge on Treatment for Hepatitis B

Journal of Bacteriology and Virology 2020년 50권 3호 p.175 ~ 180
이혜원, 최용욱, 박용광,
소속 상세정보
이혜원 ( Lee Hye-Won ) - Korea National Institute of Health Center for Infectious Disease Research Division of Viral Disease Research
최용욱 ( Choi Yong-Wook ) - Korea National Institute of Health Center for Infectious Disease Research Division of Viral Disease Research
박용광 ( Park Yong-Kwang ) - Korea National Institute of Health Center for Infectious Disease Research Division of Viral Disease Research

Abstract


Hepatitis B virus (HBV) infection is a major public health problem, with some 250 million people currently at high risk of developing chronic liver diseases. The current antiviral treatment for chronic hepatitis B (CHB) is effective in controlling viral replication but fails to achieve a complete cure. Since the identification of sodium taurocholate cotransport polypeptide (NTCP) as an HBV receptor, anti-HBV drugs targeting viral entry, capsid assembly, cccDNA, transcription, and secretion have been developed. In this paper, the potential inhibitors in various steps of the HBV life cycle are summarized.

키워드

Hepatitis B virus; Drugs; cccDNA; ISG20

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