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In Vitro Virucidal Effect of Povidone-Iodine Against SARS-CoV-2

Journal of Bacteriology and Virology 2020년 50권 3호 p.195 ~ 202
신경렬, 곽경희, Cui Chunguang, 배준용, 홍우성, 박만성,
소속 상세정보
신경렬 ( Shin Kyeong-Ryeol ) - Korea University College of Medicine Department of Microbiology
곽경희 ( Kwak Kyung-Hee ) - Mundipharma Korea Ltd.
 ( Cui Chunguang ) - Korea University College of Medicine Department of Microbiology
배준용 ( Bae Joon-Yong ) - Hallym University College of Medicine Department of Microbiology
홍우성 ( Hong Woo-Sung ) - Mundipharma Korea Ltd.
박만성 ( Park Man-Seong ) - Korea University College of Medicine Department of Microbiology

Abstract


As of September 2020, SARS-CoV-2 has infected over 30 million people worldwide, and the death toll has now risen to 950,000. Given that Povidone-iodine (PVP-I) had consistently been showing the virucidal efficacy against various types of viruses, such as SARS-CoV, MERS-CoV, and Ebola, we conducted this study to figure out the virucidal effect against SARS-CoV-2 by using a viral plaque assay. We performed Kill-Time assays to assess the viral inactivation of SARS-CoV-2contaminants after the application of the PVP-I product (Betadine® Throat Spray, PVP-I 0.45%). This test consisted of clean and dirty conditions and was designed to check the viral titers at a contact time of 60 seconds, which were evaluated by plaque-reduction rates in Vero cells. This PVP-I product fully achieved ≥4 log 10reductions in viral titers under both clean and dirty conditions. This level of reduction, ≥4 log 10 (99.99%), in viral titers presented to be effective in terms of virucidal efficacy, according to the European standards, EN14476. This study revealed the virucidal efficacy of Betadine® Throat Spray against SARS-CoV-2 virus. Given that the convenience and availability of this product, we think that it may contribute to inhibit viral infection and transmissibility as an active type of personal protective equipment (PPE) by managing the hygiene of patients and medical professionals.

키워드

COVID-19; SARS-CoV-2; Plaque; Povidone-iodine; Virucidal effect

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