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Crosstalk between the Producers and Immune Targets of IL-9

Immune Network 2020년 20권 6호 p.45 ~ 45
Do-Thi Van Anh, 이지오, 이하영, 김용상,
소속 상세정보
 ( Do-Thi Van Anh ) - Pohang University of Science and Technology Department of Life Science
이지오 ( Lee Jie-Oh ) - Pohang University of Science and Technology Department of Life Science
이하영 ( Lee Hay-Young ) - Chungnam National University Institute of Biotechnology
김용상 ( Kim Young-Sang ) - Chungnam National University College of Natural Sciences Department of Biochemistry

Abstract


IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other cellular components may provide important keys to explain its conflicting effects in chronic conditions. In this review, we summarize recent findings on the cellular sources of, and immunological responders to IL-9, in order to interpret the role of IL-9 in the regulation of immune responses. This knowledge will provide new perspectives to improve clinical benefits and limit adverse effects of IL-9 when treating pathologic conditions.

키워드

Interleukin-9; Autoimmune diseases; Allergy; Cancer, Adaptive immunity; Innate immunity

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