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Interleukin-10-Producing B Cells Help Suppress Ovariectomy-Mediated Osteoporosis

Immune Network 2020년 20권 6호 p.50 ~ 50
Wang Yuhua, Zhang Wei, 임성민, Xu Li, 진준오,
소속 상세정보
 ( Wang Yuhua ) - Shanghai Jiao Tong University School of Medicine Ninth People’s Hospital Department of Prosthodontics
 ( Zhang Wei ) - Fudan University Shanghai Medical College Shanghai Public Health Clinical Center
임성민 ( Lim Seong-Min ) - Yeungnam University Department of Medical Biotechnology
 ( Xu Li ) - Fudan University Shanghai Medical College Shanghai Public Health Clinical Center
진준오 ( Jin Jun-O ) - Yeungnam University Department of Medical Biotechnology

Abstract


Osteoporosis is prevalent in elderly women and it may cause dental implant failure. In particular, estrogen deficiency in postmenopausal women leads to higher rates of osteoporosis prevalence. Immune cell-mediated effects involving the development of osteoporosis have been studied previously; however, the role of IL-10-producing regulatory B (B10) cells in osteoporosis is largely unclear. Here, we examined the role of B10 cells in osteoporosis. C57BL/6 mice were subjected to ovariectomy (OVX). Fifteen weeks after OVX surgery, the first molar of the right maxillary was extracted, and twenty-four weeks after OVX surgery, serous progression of osteoporosis was observed in the alveolar bone. Moreover, the proportion of CD19+CD5+CD1dhigh regulatory B cells, B10, and CD4+CD25+FoxP3+ regulatory T cells from the spleen of OVX mice decreased during the progression of osteoporosis, compared to controls. In contrast to regulatory cells, IL-17-producing Th (Th17) cell levels were increased in OVX mice. Adoptive transfer of B10 cells to OVX mice led to a decrease in Th17 cell abundance and inhibited the development of osteoporosis in the alveolar bone from OVX mice. Thus, our results suggest that B10 cells may help suppress osteoporosis development.

키워드

Osteoporosis; Ovariectomy; Breg cells; Treg cells; Th17 cells; Adoptive transfer

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