잠시만 기다려 주세요. 로딩중입니다.

Antipsychotic Medication in Schizophrenic Patients is Associated with Higher Risks of Developing Bone Fractures and Refractures

Clinical Psychopharmacology and Neuroscience 2020년 18권 4호 p.562 ~ 570
Kuo Ching-Min, Liao Wei-Jen, Huang Chun-Che, Lan Tsuo-Hung, Lin Ching-Heng, Wang Shun-Ping, Lee Cheng-Hung, Lui Ping-Wing,
소속 상세정보
 ( Kuo Ching-Min ) - Taichung Veterans General Hospital Department of Psychiatry
 ( Liao Wei-Jen ) - Taichung Veterans General Hospital Department of Orthopedics
 ( Huang Chun-Che ) - I-Shou University Department of Healthcare Administration
 ( Lan Tsuo-Hung ) - Taichung Veterans General Hospital Department of Psychiatry
 ( Lin Ching-Heng ) - Taichung Veterans General Hospital Health Medical Research
 ( Wang Shun-Ping ) - Taichung Veterans General Hospital Department of Orthopedics
 ( Lee Cheng-Hung ) - Taichung Veterans General Hospital Department of Orthopedics
 ( Lui Ping-Wing ) - Taichung Veterans General Hospital Department of Anesthesiology

Abstract


Objective: The relationship of antipsychotics and the risk of refracture in treated patients is unclear. The aim of this study is to evaluate the association between prolonged antipsychotic and the incidences of bone fractures and refractures in schizophrenia.

Methods: This is a retrospective nested case-control study using Taiwan National Health Insurance Research Database recorded from 2000 to 2005, with cases followed up to end of 2011. Total of 7,842 schizophrenic patients, 3,955 had developed bone fractures were compared with 3,887 control subjects matched in age, sex, and index date. Antipsychotic drug exposure was classified based on the drug type and medication duration. Conditional logistic regression analyses were performed. Odds ratio (OR) and confidence interval (CI) were calculated.

Results: We found (after adjustments) higher risks of developing fractures under continued use of typical (OR = 1.70; 95% CI, 1.51?1.91) or atypical antipsychotics (OR = 1.43; 95% CI, 1.28?1.60) were found. Additionally, continued use typical (OR = 1.84; 95% CI, 1.35?2.50) or atypical antipsychotics (OR = 1.44; 95% CI, 1.06?1.95) was positively associated with refracture risks. Moreover, refractures were associated with continuous use of chlorpromazine (one typical antipsychotics, OR = 2.45; 95% CI, 1.14?5.25), and risperidone (OR = 1.48; 95% CI, 1.01?2.16) or zotepine (OR = 2.15; 95% CI, 1.06?4.36) (two atypical antipsychotics).

Conclusion: Higher risks of bone fracture and refracture were found in schizophrenia under prolonged medication with typical or atypical antipsychotics. We therefore recommend that clinicians should pay more attention on bone density monitoring for patients using long-term antipsychotics.

키워드

Antipsychotic agents; Fracture; Refracture; Schizophrenia

원문 및 링크아웃 정보

 

등재저널 정보