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In a case of female-to-male sex reassignment, testosterone therapy switches on an underlying Brugada

International Journal of Arrhythmia 2020년 21권 1호 p.17 ~ 17
Vivona Patrizia, Dagradi Federica, Ciulla Michele M.,
소속 상세정보
 ( Vivona Patrizia ) - University of Milan Department of Clinical Sciences and Community Health
 ( Dagradi Federica ) - IRCCS Istituto Auxologico Italiano
 ( Ciulla Michele M. ) - University of Milan Department of Clinical Sciences and Community Health

Abstract


Background: The Brugada syndrome, diagnosed by a typical electrocardiographic pattern, is a genetic condition characterised by an increased risk of potentially lethal ventricular arrhythmias and sudden cardiac death. Even if its pathophysiological mechanism is unknown, its prevalence in male suggested a possible hormonal involvement.

Case presentation: In this case involving a woman who underwent a female-to-male sex reassignment, we documented that testosterone administration was able to switch on and, when stopped, to switch off a latent pattern of Brugada.

Conclusions: Our observation strongly supports a possible involvement of testosterone in the ECG manifestation of Brugada syndrome even if the general low prevalence of the Brugada syndrome does not support to screen every female-to-male sex reassignment.

키워드

Brugada syndrome; Testosterone; Sex change

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