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The Relationship between Serum Vitamin C and Uric Acid Levels, Antioxidant Status and Coronary Artery Disease: a Case-Control Study

Clinical Nutrition Research 2020년 9권 4호 p.307 ~ 317
Torkzaban Aida, Naeini Amirmansour Alavi, Hassanzadeh Akbar, Namdari Mehrdad,
소속 상세정보
 ( Torkzaban Aida ) - Isfahan University of Medical Sciences School of Nutrition and Food Science Department of Community Nutrition
 ( Naeini Amirmansour Alavi ) - Isfahan University of Medical Sciences School of Nutrition and Food Science Department of Community Nutrition
 ( Hassanzadeh Akbar ) - Isfahan University of Medical Sciences School of Health Department of Biostatistics and Epidemiology
 ( Namdari Mehrdad ) - Lorestan University of Medical Sciences Medical School

Abstract


Coronary artery disease (CAD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are affecting factors in the progress of atherosclerosis. The aim of this study was to measure serum levels of uric acid (UA) and vitamin C as well as the antioxidant status in patients with CAD, and compared them with those in healthy individuals. The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. The Food Frequency Questionnaire (FFQ) and International Physical Activity Questionnaire (IPAQ) were completed. After 12 hours of fasting,10 mL blood was sampled from the participants. Serum levels of UA, vitamin C, Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) were also measured. The data were finally analyzed by SPSS v22. A significant difference was observed between the groups in terms of UA and vitamin C. However, mean levels of MDA and TAC were not significantly different between groups. The differences between groups in terms of vitamin A, vitamin E, beta-carotene, zinc and selenium intakes were not significant either. A significant difference was detected between the groups in terms of vitamin C intake. Our results suggest that increase in UA and decrease in vitamin C in serum levels can be considered as risk factors for CAD patients. Due to a lack of any significant correlation between TAC and CAD risk in this study, further study with bigger sample size is needed.

키워드

Ascorbic acid; Uric acid; Atherosclerosis; Coronary artery disease

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