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Additional diagnostic testing of the 2019 novel coronavirus (SARS-CoV-2)

Molecular & Cellular Toxicology 2020년 16권 4호 p.355 ~ 357
Vo Van Giau, Bagyinszky Eva, 심규환, 박윤수, 안성수,
소속 상세정보
 ( Vo Van Giau ) - Gachon University Graduate School of Environment Department of Industrial and Environmental Engineering
 ( Bagyinszky Eva ) - Gachon University Graduate School of Environment Department of Industrial and Environmental Engineering
심규환 ( Shim Kyu-Hwan ) - Gachon University Department of Bionanotechnology
박윤수 ( Park Yoon-Soo ) - Yonsei University College of Medicine Yongin Severance Hospital Department of Internal Medicine
안성수 ( An Seong-Soo A. ) - Gachon University Department of Bionanotechnology

Abstract


Purpose of review: Within the last two decades several members of the Coronaviridae family namely Severe Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) have demonstrated epidemic potential. In late, 2019 an unnamed genetic relative, later named SARS-CoV-2 realized its potential in the highly populous neighborhoods of Wuhan, China. Unchecked, the virus rapidly spread among interconnected communities and related households before containment measures could be in acted. “Appropriate” diagnostic testing in response to the SARS-CoV-2 outbreak should be urgently considered. This perspective review gives particular attention to the potential diagnostic testing of the virus in semen and seminal fluids due to its high levels of angiotensin converting enzyme 2 (ACE2) precursor.

Recent findings: As many infectious viruses are stable in semen and have transmitted the respective diseases, the presence of SARS-CoV-2 should be tested in semen to assess their stabilities and half-life. As in case of Ebola virus, it was present in semen for longer period in a carrier man without any symptom. Additional hypothesis is that since ACE2 could serve as a mediator for the endocytosis of the previously SARS coronavirus, SARS-CoV-2 may enter the cells through similar mechanism. From the protein expression atlas, high levels of ACE2 precursor were found in intestines and testis. Hence, the testis and seminal fluids could be the host cell and/or reservoir. The results could be used as a suggestive guideline for the sexual activities after the discharge or declaration of disease free.

키워드

SARS-CoV-2; ACE2; Semen; Testes; Seminal vesicles

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