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Comparative analysis of acute and chronic stress-induced neurobehavioral alteration and liver injury in mice

Molecular & Cellular Toxicology 2020년 16권 4호 p.367 ~ 375
오태우, 김광연, 도현주, 김영우, 박광일,
소속 상세정보
오태우 ( Oh Tae-Woo ) - Korea Institute of Oriental Medicine Korean Medicine Application Center
김광연 ( Kim Kwang-Youn ) - Korea Institute of Oriental Medicine Korean Medicine Application Center
도현주 ( Do Hyun-Ju ) - Korea Institute of Oriental Medicine Korean Medicine Application Center
김영우 ( Kim Young-Woo ) - Dongguk University College of Korean Medicine
박광일 ( Park Kwang-Il ) - Gyeongsang National University College of Veterinary Medicine

Abstract


Backgrounds: Recent research has shown that stress has a significant influence on the functions of many organs.

Objective: The present study investigated the effect of acute or chronic restraint stress on physiological and psychological processes.

Results: In the acute stress group, body weight and food intake did not change, but in the chronic stress group, food intake significantly increased and body weight was significantly inhibited. ALT and AST levels were significantly increased by both groups. Acute and chronic restraint stress led to different behavioral changes. Serum levels of corticosterone and cortisol were more increased in chronic stress than in acute stress. The levels of neurons and astrocyte in the hippocampus, and the NeuN-positive neuronal cells remained unaffected by acute stress, but were decreased by chronic stress. GFAP-positive astrocytes were increased by both groups.

Conclusion: In summary, our study provides evidence of a relationship between liver injury and behavioral change upon exposure to restraint stress.

키워드

Restraint stress; Liver injury; Neuronal cell death; Behavioral change; Depressive-like symptoms; Anxiety-like behavior

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