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Capture and toxicity assessment of Ag citrate nanoparticles using jellyfish extract

Molecular & Cellular Toxicology 2020년 16권 4호 p.431 ~ 439
하지운, 김은아, 이봉구, 여민경,
소속 상세정보
하지운 ( Ha Ji-Won ) - Kyung Hee University Graduate School Department of Applied Environmental Science
김은아 ( Kim Eun-A ) - Kyung Hee University Graduate School Department of Applied Environmental Science
이봉구 ( Lee Bong-Gu ) - Kyung Hee University Graduate School Department of Applied Environmental Science
여민경 ( Yeo Min-Kyeong ) - Kyung Hee University Graduate School Department of Applied Environmental Science

Abstract


Backgrounds: In this study, Jellyfish extract at immunity reaction (JEI) captured Ag citrate nanoparticles (Ag citrate NPs) and reduce toxicity was investigated.

Methods: JEI obtained from Aurelia aurita was used to assess the capture of Ag citrate NPs (10 mg/L, 2 mg/L) during 24 h, and the toxicity of JEI was assessed using a human cell line BEAS-2B.

Results: JEI was to reduce Ag citrate NPs in water by 34.55% (10 mg/L) after 1 h and by 40.62?~?41% (2 mg/L, 10 mg/L) after 24 h. When the BEAS-2B was exposed to 2 mg/L of Ag citrate NPs mixed with JEI showed increase 33.97% survival than 2 mg/L of Ag citrate NPs (0%). Furthermore, the apoptosis-related genes (p53, Bcl2, and Bax) showed no significant difference in expression upon exposure to JEI, compared to the control.

Conclusion: JEI is to capture Ag citrate NPs and reduce its nano-toxicity. Therefore, such ability of JEI is likely to prove useful in the control of AgNPs flowing into the aquatic ecosystem.

키워드

Ag citrate nanoparticle; BEAS-2B cell line; Immunity reaction; Jellyfish extract; Nano-toxicity

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