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Effects of α-mangostin on embryonic development and liver development in zebrafish

Molecular & Cellular Toxicology 2020년 16권 4호 p.469 ~ 476
Pimtong Wittaya, Kitipaspallop Wannakarn, Chun Hang-Suk, 김우근,
소속 상세정보
 ( Pimtong Wittaya ) - National Science and Technology Development Agency National Nanotechnology Center Nano Environmental and Health Safety Research Team
 ( Kitipaspallop Wannakarn ) - Chulalongkorn University Faculty of Science Department of Biology
 ( Chun Hang-Suk ) - Korea Institute of Toxicology Biosystem Research Group
김우근 ( Kim Woo-Keun ) - Korea Institute of Toxicology Biosystem Research Group

Abstract


Background: Alpha-mangostin has potential as a chemopreventive agent but there is little information on its toxicological profile and developmental toxicity.

Objective: We evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish.

Result: Exposure of embryos to 0.25?4 μM α-mangostin from 4?120 h post-fertilization (hpf) caused mortality of embryos with LC50 1.48?±?0.29 μM. The compound also caused deformities, including head malformation, pericardial oedema, absence of swim bladder, yolk oedema, and bent tail. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16?72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. In Fabp10a:DsRed transgenic zebrafish, the intensity and the area of fluorescence in the liver of the treated group were decreased (non-significantly) relative to controls.

Conclusion: These effects were more marked during early hepatogenesis (16?72 hpf) than during post-hepatogenesis (72?120 hpf).

키워드

α-Mangostin; Xanthone; Zebrafish; Hepatogenesis; Toxicity

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