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A National Consensus Survey for Current Practice in Brain Tumor Management II: Diffuse Midline Glioma and Meningioma

Brain Tumor Research and Treatment : BTRT 2020년 8권 1호 p.11 ~ 19
김승권, Yoon Hong-In, 윤완수, 조진모, 문장섭, 김경환, 김세훈, 김영일, 김영준, 김호성, Dho Yun-Sik, 박재성, 박지은, 서영범, Sung Kyoung-Su, 송진호, 위찬우, 이세훈, 임도훈, 임정호, 장종희, 한명훈, 홍제범, Hwang Ki-Hwan, 박철기, 이연수, 곽호신,
소속 상세정보
김승권 ( Kim Sung-Kwon ) - Gyeongsang National University Changwon Hospital Department of Neurosurgery
 ( Yoon Hong-In ) - Yonsei University College of Medicine Yonsei Cancer Center Department of Radiation Oncology
윤완수 ( Yoon Wan-Soo ) - Catholic University College of Medicine Incheon St. Mary’s hospital Department of Neurosurgery
조진모 ( Cho Jin-Mo ) - Catholic Kwandong University International St. Mary’s Hospital Department of Neurosurgery
문장섭 ( Moon Jang-Sup ) - Seoul National University Hospital Department of Neurology
김경환 ( Kim Kyung-Hwan ) - Chungnam National University School of Medicine Chungnam National University Hospital Department of Neurosurgery
김세훈 ( Kim Se-Hoon ) - Yonsei University College of Medicine Severance Hospital Department of Pathology
김영일 ( Kim Young-Il ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Neurosurgery
김영준 ( Kim Young-Zoon ) - Sungkyunkwan University School of Medicine Samsung Changwon Hospital Department of Neurosurgery
김호성 ( Kim Ho-Sung ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
 ( Dho Yun-Sik ) - Chungbuk National University College of Medicine Chungbuk National University Hospital Department of Neurosurgery
박재성 ( Park Jae-Sung ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Neurosurgery
박지은 ( Park Ji-Eun ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
서영범 ( Seo Young-Beom ) - Yeungnam University Hospital Department of Neurosurgery
 ( Sung Kyoung-Su ) - Dong-A University College of Medicine Dong-A University Hospital Department of Neurosurgery
송진호 ( Song Jin-Ho ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Radiation Oncology
위찬우 ( Wee Chan-Woo ) - Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Radiation Oncology
이세훈 ( Lee Se-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
임도훈 ( Lim Do-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
임정호 ( Im Jung-Ho ) - CHA University CHA Bundang Medical Center Department of Radiation Oncology
장종희 ( Chang Jong-Hee ) - Yonsei University College of Medicine Severance Hospital Department of Neurosurgery
한명훈 ( Han Myung-Hoon ) - Hanyang University Guri Hospital Department of Neurosurgery
홍제범 ( Hong Je-Beom ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Neurosurgery
 ( Hwang Ki-Hwan ) - Seoul National University Bundang Hospital Department of Neurosurgery
박철기 ( Park Chul-Kee ) - Seoul National University College of Medicine Seoul National University Hospital Department of Neurosurgery
이연수 ( Lee Youn-Soo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Hospital Pathology
곽호신 ( Gwak Ho-Shin ) - National Cancer Center Graduate School of Cancer Science and Policy Department of Cancer Control

Abstract


Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part II of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with diffuse midline glioma and meningioma.

Methods: A web-based survey was sent to all members of the KSNO by email. The survey included 4 questions of diffuse midline glioma and 6 questions of meningioma (including 2 case scenarios). All questions were developed by consensus of the Guideline Working Group.

Results: In the survey about diffuse midline glioma, 76% respondents performed histologic confirmation to identify H3K27M mutation on immunohistochemical staining or sequencing methods. For treatment of diffuse midline glioma, respondents preferred concurrent chemoradiotherapy with temozolomide (TMZ) and adjuvant TMZ (63.8%) than radiotherapy alone (34.0%). In the survey about meningioma, respondents prefer wait-and-see policy for the asymptomatic small meningioma without peritumoral edema. However, a greater number of respondents had chosen surgical resection as the first choice for all large size meningiomas without exception, and small size meningiomas with either peritumoral edema or eloquent location. There was no single opinion with major consensus on long-term follow-up plans for asymptomatic meningioma with observation policy. As many as 68.1% of respondents answered that they would not add any adjuvant therapies for World Health Organization grade II meningiomas if the tumor was totally resected including dura.

Conclusion: The survey demonstrates the prevailing clinical practice patterns for patients with diffuse midline glioma and meningioma among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of diffuse midline glioma and meningioma.

키워드

Korean Society for Neuro-Oncology; Practice patterns; Brain tumors; Diffuse midline glioma; Meningioma, Guideline Working Group

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