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큰눈자미 배아의 식물성 스테롤 함량 및 성숙기 흰쥐에서 항산화 효과

Phytosterols content of Keunnunjami germ and its antioxidative effects in adult rats

Journal of Nutrition and Health 2020년 53권 2호 p.99 ~ 110
량지에, 마징원, 정수임, 강미영,
소속 상세정보
량지에 ( Liang Jie ) - Kyungpook National University Department of Food Science and Nutrition
마징원 ( Ma Jing-Wen ) - Kyungpook National University Department of Food Science and Nutrition
정수임 ( Chung Soo-Im ) - Kyungpook National University Department of Food Science and Nutrition
강미영 ( Kang Mi-Young ) - Kyungpook National University Department of Food Science and Nutrition

Abstract


Purpose: The rice germ fraction is a better source of protein, lipid, and fiber than the rice endosperm. Furthermore, the rice germ is rich in bioactive phytochemicals such as γ-aminobutyric acid, tocopherols, tocotrienols, phytic acid, and so on. In this study, the phytosterol content and antioxidant activity of Keunnunjami germ (KG) or normal rice germ supplement were investigated in healthy adult rats.

Methods: In vitro, quantitative assessment of phytosterols, including β-sitosterol, campesterol, cycloartenol, and stigmasterol, was performed. Comparative antioxidant activities of 2 rice germs were measured based on DPPH radical scavenging activity, reducing power, and ABTS radical scavenging capacity. In vivo, male Spraque-Dawley rats (30-weeks-old) were randomly assigned a diet of normal control (NC, AIN-93M diet), AIN-93M diet supplemented with normal rice germ 3% (NG3), or AIN-93M diet supplemented with KG 3% (KG3) and fed for 8 weeks.

Results: KG contained significantly higher campesterol and stigmasterol contents and antioxidant activity than normal rice germ. The KG3 group exhibited significantly lower body weight gain as well as inguinal and total white adipose tissue weights. There were no significant differences in plasma glucose, insulin, C-peptide, or homeostasis model assessment of insulin resistance level among the 3 groups. The plasma tumor necrosis factor-α concentration was significantly lower while leptin, advanced oxidation protein products, and interleukin-6 showed downward trends in the KG3 group. In addition, the superoxide dismutase level of the KG3 group was significantly higher compared to the NC and NG3 groups.

Conclusion: This study indicates that KG can be considered as a valuable source of phytosterol components. Lastly, KG has strong antioxidant properties and may have potential to ameliorate elevation of proinflammatory cytokine production with age.

키워드

antioxidants; functional food; cytokines; phytosterols; rice

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