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한식의 체내 대사에 미치는 영향에 대한 연구: 소변 유기산 분석을 통한 한식의 효과

Traditional Korean diet can alter the urine organic acid profile, which may reflect the metabolic influence of the diet

Journal of Nutrition and Health 2020년 53권 3호 p.231 ~ 243
신필경, 천수경, 김명선, 박선주, 김민정, 권대영, 김경철, 이해정, 최상운,
소속 상세정보
신필경 ( Shin Phil-Kyung ) - CHA University
천수경 ( Chun Su-Kyung ) - CHA University
김명선 ( Kim Myung-Sunny ) - Korea Food Research Institute
박선주 ( Park Seon-Joo ) - Gachon University College of BioNano Technology Department of Food and Nutrition
김민정 ( Kim Min-Jung ) - Korea Food Research Institute
권대영 ( Kwon Dae-Young ) - Korea Food Research Institute
김경철 ( Kim Kyong-Chol ) - GangNam Major Hospital
이해정 ( Lee Hae-Jeung ) - Gachon University College of BioNano Technology Department of Food and Nutrition
최상운 ( Choi Sang-Woon ) - CHA University Chaum Life Center

Abstract


Purpose: To determine the metabolic influence of the traditional Korean diet (K-diet), which has been regarded as a healthy diet, we investigated the profile of urine organic acids that are intermediates of various types of metabolism including energy metabolism.

Methods: Ten women aged 50?60 years were recruited and randomly divided into 2 diet groups, K-diet and control diet, the latter of which is a Westernized Korean diet that is commonly consumed by Koreans nowadays. Before and after the 2-week intervention, 46 urine organic acids were determined using LC/MS/MS, along with clinical parameters.

Results: The average concentrations of succinate (4.14 ± 0.84 μg/mg creatinine vs. 1.49 ± 0.11, p = 0.0346) and hydroxymethylglutarate (3.67 ± 0.36 μg/mg creatinine vs. 2.97 ± 0.29, p = 0.0466), both of which are intermediates of energy metabolism, decreased in the K-diet group after the 2-week intervention, but these were not observed in the control diet group. In particular, the average concentration of succinate in the K-diet group was lower than that in the control group (3.33 ± 0.56 μg/mg creatinine vs. 1.49 ± 0.11, p = 0.0284) after 2 weeks. The concentrations of two tryptophan metabolites, 5-hydroxyindolacetate (3.72 ± 0.22 μg/mg creatinine vs. 3.14 ± 0.21, p = 0.0183) and indican (76.99 ± 8.35 μg/mg creatinine vs. 37.89 ± 10.06, p = 0.0205) also decreased only in the K-diet group. After the 2-week intervention, the concentration of kynurenate, another tryptophan metabolite, was lower in the K-diet group than that in the control diet group (3.96 ± 0.51 μg/mg creatinine vs. 2.90 ± 0.22, p = 0.0356). Interestingly, the urine level of kynurenate was positively correlated with BMI (r = 0.61424, p = 0.0003) and total cholesterol (r = 0.46979, p = 0.0088), which decreased only in the K-diet group (239.40 ± 15.14 mg/dL vs. 198.20 ± 13.25, p = 0.0163).

Conclusion: The K-diet alters the urinary excretion of organic acids involved in energy metabolism and tryptophan metabolism, suggesting the influence of the K-diet on these types of metabolism. Urine organic acids changed by the K-diet may serve as biomarkers in future studies.

키워드

Korean diet; urine organic acid; succinate; hydroxymethylglutarate; kynurenate

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