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선씀바귀 추출물의 항산화 및 항당뇨 효과

Antioxidant and anti-diabetic effects of Ixeris strigosa extract

Journal of Nutrition and Health 2020년 53권 3호 p.244 ~ 254
지윤정, 이은영, 이지연, 서경혜, 김동휘, 박춘근, 김형돈,
소속 상세정보
지윤정 ( Ji Yun-Jeong ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
이은영 ( Lee Eun-Young ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
이지연 ( Lee Ji-Yeon ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
서경혜 ( Seo Kyung-Hye ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
김동휘 ( Kim Dong-Hwi ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
박춘근 ( Park Chun-Geon ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research
김형돈 ( Kim Hyung-Don ) - National Instiute of Horticultural & Herbal Science Department of Herbal Crop Research

Abstract


Purpose: Ixeris strigosa (IS) is a perennial plant that commonly grows in meadows. The leaves and roots of IS have been used in medicine as a sedative. This study evaluated the antioxidant and carbohydrate-digestive-enzyme inhibitory effects of IS to determine its potential as an essential antioxidant and glycemic inhibitor for type 2 diabetics.

Methods: The antioxidative and α-amylase and α-glucosidase inhibitory activities were examined using the water extracts (ISW), ethanol extracts (ISE), and solvent fractions from IS. The antioxidative activities were measured using in vitro methods by measuring the 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical scavenging activity.

Results: Investigations of the total polyphenol, flavonoid content, in vitro antioxidant activity, and α-amylase and α-glucosidase inhibitory activities of the IS extract showed that the ISE had higher total phenolic and flavonoid contents than the ISW, as well as high antioxidant activity. The ethanolic extracts of IS (70%) had an α-amylase inhibitory activity of 78.55%. The ethyl acetate fraction (90.56%) showed higher α-glucosidase inhibitory activity than the positive control, acarbose (83.01%).

Conclusion: Among the ISE fractions, the ethyl acetate and butanol fractions showed the best digestive enzyme inhibitory activity. Moreover, the antioxidant activity of the extract and the carbohydrate, α-amylase, and α-glucosidase inhibitory effects showed a stronger correlation with the total phenol and flavonoid contents compared to the ISW. As a result, the antioxidant and digestive enzyme inhibitory activities of high ISE are due to the phenolic compounds, particularly the flavonoid compounds. Therefore, ethyl acetate and butanol fractions of the 70% ethanol extract are excellent anti-diabetic functional materials.

키워드

Ixeris strigosa; antioxidant; α-amylase; α-glucosidase

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