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Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age

Annals of Pediatric Endocrinology & Metabolism 2020년 25권 1호 p.38 ~ 41
Ellison Benjamin R., Burton Jeffrey H., Hsia Daniel S.,
소속 상세정보
 ( Ellison Benjamin R. ) - Baylor University
 ( Burton Jeffrey H. ) - Pennington Biomedical Research Center
 ( Hsia Daniel S. ) - Pennington Biomedical Research Center

Abstract


Purpose: This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio.

Methods: Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters.

Results: The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2 =0.61, P=0.02) in the type 1 diabetes group.

Conclusions: Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children.

키워드

Proinsulin; C-peptide; Type 1 diabetes mellitus; Biomarkers

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