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Serum uric acid in Korean children and adolescents: reference percentiles and association with metabolic syndrome

Annals of Pediatric Endocrinology & Metabolism 2020년 25권 2호 p.104 ~ 111
조명현, 김윤모, 윤종형, 김동호, 임중섭,
소속 상세정보
조명현 ( Cho Myung-Hyun ) - Korea Cancer Center Hospital Department of Pediatrics
김윤모 ( Kim Yoon-Mo ) - Korea Cancer Center Hospital Department of Pediatrics
윤종형 ( Yoon Jong-Hyung ) - Korea Cancer Center Hospital Department of Pediatrics
김동호 ( Kim Dong-Ho ) - Korea Cancer Center Hospital Department of Pediatrics
임중섭 ( Lim Jung-Sub ) - Korea Cancer Center Hospital Department of Pediatrics

Abstract


Purpose: To establish age/sex-specific reference intervals for serum uric acid and to examine the associations between serum uric acid level and metabolic syndrome (MetS) and its components in Korean children and adolescents.

Methods: We analyzed data for 1,349 subjects aged 10 to 19 years from the Korea National Health and Nutrition Examination Survey 2016?2017.

Results: The mean uric acid levels were 5.9±1.3 mg/dL (interquartile range, 5.0?6.8 mg/dL) in males and 4.6±0.9 mg/dL (interquartile range, 3.9?5.2 mg/dL) in females. The mean uric acid level increased significantly from 10?13 years of age in males, but not in females. The overall prevalence of MetS was 5.9% (7.3% in males and 4.3% in females; P=0.022). The prevalences of MetS in the lowest, second, third, and highest quartiles of uric acid level were 4.4%, 3.3%, 6.1%, and 15.2%, respectively, in males (P for trend <0.001) and 1.9%, 0.0%, 4.1%, and 10.9%, respectively, in females (P for trend <0.001). Compared with the lowest quartile of uric acid level, the odds ratio (with 95% confidence interval) for MetS in the highest quartile was 2.897 (1.140?7.361) in males and 5.173 (1.459?18.342) in females. Subjects in the highest quartile exhibited increased risk for abdominal obesity and low high-density lipoprotein cholesterol in both sexes.

Conclusions: Serum uric acid level is positively associated with MetS and its components abdominal obesity and low high-density lipoprotein cholesterol.

키워드

Adolescent; Metabolic syndrome; Uric acid; Obesity

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