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Human Fibroblast-derived Multi-peptide Factors and the Use of Energy-delivering Devices in Asian Patients

서상범, 안근재, 정혜진, Suh Ji-Youn, 조성빈,
소속 상세정보
서상범 ( Suh Sang-Bum ) - BNV Biolab R&D Center
안근재 ( Ahn Keun-Jae ) - Jeju National University Department of Science Education
정혜진 ( Chung Hye-Jin ) - Beth Israel Deaconess Medical Center Department of Dermatology
 ( Suh Ji-Youn ) - BNV Biolab R&D Center
조성빈 ( Cho Sung-Bin ) - Yonsei Seran Dermatology and Laser Clinic

Abstract


Human fibroblast-derived multi-peptide factors (MPFs) have been used during treatments with energy-delivering modalities to enhance energyinduced tissue reactions. Human fibroblast-derived MPFs, which include a range of growth factors and chemoattractive factors, activate and recruit fibroblasts and endothelial cells, as well as promote extracellular matrix deposition, all of which are crucial to wound repair. Interestingly, fibroblasts from different species or anatomical sites exhibit distinct transcriptional properties with high heterogeneity. In addition, the patterns of MPF secretion can differ under a range of experimental conditions. Therefore, the use of allogeneic fibroblasts and proper cultivation thereof are necessary to obtain MPFs that can enhance the epithelial-mesenchymal interactions during wound repair. Moreover, energy-delivering devices should be selected according to evidence demonstrating their therapeutic efficacy and safety on a pathological skin condition and the major target skin layers. This paper reviewed the histologic patterns of post-treatment tissue reactions elicited by several energy sources, including non-ablative and ablative fractional lasers, intense focused ultrasound, non-invasive and invasive radiofrequency, picosecond-domain lasers, and argon and nitrogen plasma. The possible role of the immediate application of human fibroblast-derived MPFs during wound repair was proposed.

키워드

Fibroblast-derived multi-peptide factors; Energy-delivering system; Radiofrequency; Fractional laser; Ultrasound; Picosecond-domain laser; Plasma; Argon; Nitrogen

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