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Validation of SwimCount™, a Novel Home-Based Device That Detects Progressively Motile Spermatozoa: Correlation with World Health Organization 5th Semen Analysis

The World Journal of Men′s Health 2020년 38권 2호 p.191 ~ 197
윤영은, Kim Tae-Yoon, Shin Tai-Eun, 이은지, 최경화, 이승렬, 홍영권, 박동수, 김대근,
소속 상세정보
윤영은 ( Yoon Young-Eun ) - Hanyang University College of Medicine Department of Urology
 ( Kim Tae-Yoon ) - CHA Fertility Center Seoul Station TopHealth Company
 ( Shin Tai-Eun ) - CHA Fertility Center Seoul Station Andrology Laboratory
이은지 ( Lee Eun-Ji ) - CHA Fertility Center Seoul Station Andrology Laboratory
최경화 ( Choi Kyung-Hwa ) - CHA University CHA Bundang Medical Center Department of Urology
이승렬 ( Lee Seung-Ryeol ) - CHA University CHA Bundang Medical Center Department of Urology
홍영권 ( Hong Young-Kwon ) - CHA University CHA Bundang Medical Center Department of Urology
박동수 ( Park Dong-Soo ) - CHA University CHA Bundang Medical Center Department of Urology
김대근 ( Kim Dae-Keun ) - CHA University Department of Urology

Abstract


Purpose: We evaluated the usefulness of a home-based device (SwimCount™) compared with World Health Organization (WHO) 5th semen analysis in screening for male fertility in Asian men.

Materials and Methods: One hundred Asian men who visited CHA Seoul Station Fertility Center for evaluation of fertility were included. Semen samples were analyzed and compared with the SwimCount™ results. An aliquot of 0.5 mL of the semen sample was added to the SwimCount™ and a WHO 5th semen analysis was performed. Results were categorized as low (<5×106/mL), and normal to high (≥5×106/mL) total progressively motile sperm concentration. Receiver operating characteristic curve analysis was performed to evaluate the accuracy of the SwimCount™.

Results: The mean total progressively motile sperm concentration was 26.7×106/mL. Semen analysis revealed that 28% of the samples were below the threshold count of 5 million/mL total progressively motile sperm concentration. The mean total progressively motile sperm concentration of the light color SwimCount™ result group determined by semen analysis was 7.5×106/mL, and the mean total progressively motile sperm concentration of the moderate to dark color SwimCount™ result group was 34.2×106/mL. An area under the receiver operating characteristic curve of 0.85 (95% confidence interval, 0.77?0.94; p<0.001) was obtained when the SwimCount™ was compared with semen analysis. The sensitivity and specificity were obtained at a cut off value of 5.0×106/mL total progressively motile sperm concentration, giving a sensitivity and specificity of 87.5% and 73.4%.

Conclusions: We confirmed the reliability of the SwimCount™ as a home-based device for male fertility by evaluating the total progressively motile sperm concentration.

키워드

Fertility; Spermatozoa; Sperm count; Sperm motility

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