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Demographics, Usage Patterns, and Safety of Male Users of Clomiphene in the United States

The World Journal of Men′s Health 2020년 38권 2호 p.220 ~ 225
Guo David P., Zlatev Dimitar V., Li Shufeng, Baker Laurence C., Eisenberg Michael L.,
소속 상세정보
 ( Guo David P. ) - Stanford University School of Medicine Department of Urology
 ( Zlatev Dimitar V. ) - Stanford University School of Medicine Department of Urology
 ( Li Shufeng ) - Stanford University School of Medicine Department of Urology
 ( Baker Laurence C. ) - Stanford University Department of Health Research and Policy
 ( Eisenberg Michael L. ) - Stanford University School of Medicine Department of Urology

Abstract


Purpose: The aim of this study was to characterize the demographics, usage patterns and complication rates of clomiphene use in male patients.

Materials and Methods: We retrospectively analyzed male patients from ages 20 to 55 years old who were prescribed clomiphene citrate from 2001 to 2014 using the Truven Health MarketScan, a US claims database. We collected data regarding associated medical diagnoses, diagnostic testing, duration of use, and reported side effects including thrombotic events, vision problems, gynecomastia, mental disorders, liver disease, nausea, or skin problems.

Results: In total, 12,318 men took clomiphene and represented the primary study cohort, with a mean age of 37.8 years. The percentage of men prescribed clomiphene increased over the study period, as did the average age of clomiphene users. Associated diagnoses included male infertility (52.0%), testicular hypofunction (13.5%), erectile dysfunction (2.4%), and low libido (0.4%). Associated testing included semen analysis (43.7%), testosterone (23.5%), luteinizing hormone (19.3%), and follicle-stimulating hormone (21.1%) levels. The median time of clomiphene use was 3.6 months, with 63% of men stopping within 6 months. No increased risk of reported clomiphene side effects were apparent in men taking the medication.

Conclusions: There is a rising prevalence of clomiphene usage without associated adverse side effects in the US. The variability in associated diagnoses, diagnostic testing, and duration of use suggest a need for greater awareness of the proper evaluation and treatment of the men who are prescribed clomiphene.

키워드

Clomiphene; Demography; Infertility, male; Safety

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