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Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility

The World Journal of Men′s Health 2020년 38권 4호 p.472 ~ 483
Selvam Manesh Kumar Panner, Agarwal Ashok,
소속 상세정보
 ( Selvam Manesh Kumar Panner ) - Cleveland Clinic American Center for Reproductive Medicine
 ( Agarwal Ashok ) - Cleveland Clinic American Center for Reproductive Medicine

Abstract


Male infertility is a rising problem and the etiology at the molecular level is unclear. Use of omics has provided an insight into the underlying cellular changes in the spermatozoa of infertile men. Proteomics is one the promising omics techniques for biomarker screening that can provide complete information on molecular processes associated with male infertility. Varicocele is a pressing issue in the field of male infertility and the search for an appropriate diagnostic and therapeutic biomarker is still ongoing. In this review, we discuss the reports on proteomic profiles of sperm and seminal plasma in male infertility and provide an in-depth insight into varicocele studies associated with male infertility.

키워드

Proteomics; Seminal plasma; Sperm; Varicocele

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