잠시만 기다려 주세요. 로딩중입니다.

The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review

The World Journal of Men′s Health 2020년 38권 4호 p.484 ~ 494
Karna Keshab Kumar, 신유섭, 최보람, 김혜경, 박종관,
소속 상세정보
 ( Karna Keshab Kumar ) - Chonbuk National University Medical School Department of Urology
신유섭 ( Shin Yu-Seob ) - Chonbuk National University Medical School Department of Urology
최보람 ( Choi Bo-Ram ) - Chonbuk National University Medical School Department of Urology
김혜경 ( Kim Hye-Kyung ) - Kyungsung University College of Pharmacy
박종관 ( Park Jong-Kwan ) - Chonbuk National University Medical School Department of Urology

Abstract


Endoplasmic reticulum (ER) stress, defined as prolonged disturbances in protein folding and accumulation of unfolded proteins in the ER. Perturbation of the ER, such as distribution of oxidative stress, iron imbalance, Ca2+ leakage, protein overload, and hypoxia, can cause ER stress. The cell reacts to ER stress by activating protective pathways, called the unfolded protein response (UPR), which is comprised of cellular mechanisms aimed for maintaining cellular homeostasis or, in case of excessively severe stress, at the initiation of cellular apoptosis. The three UPR signaling pathways from the ER stress sensors are initiated by activating transcription factor 6, inositol requiring enzyme 1, and protein kinase RNA-activated-like ER kinase. A number of physiological and pathological conditions, environmental toxicants and variety of pharmacological agents showed disruption of proper ER functions and thereby cause ER stress in male reproductive organ in rat model. The present review summarizes the existing data concerning the molecular and biological mechanism of ER stress in male reproduction and male infertility. ER stress initiated cell death pathway has been related to several diseases, including hypoxia, heath disease, diabetes, and Parkinson's disease. Although there is not enough evidence to prove the relationship between ER stress and male infertility in human, most studies in this review found that ER stress was correlated with male reproduction and infertility in animal models. The ER stress could be novel signaling pathway of regulating male reproductive cellular apoptosis. Infertility might be a result of disturbing the ER stress response during the process of male reproduction.

키워드

Apoptosis; Endoplasmic reticulum stress; Infertility; Oxidative stress; Reproduction

원문 및 링크아웃 정보

등재저널 정보