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Endoscopic Factors that Can Predict Histological Ulcerations in Early Gastric Cancers

Clinical Endoscopy 2020년 53권 3호 p.328 ~ 333
이재신, 김병옥, 허철웅, 김준성, 맹이소,
소속 상세정보
이재신 ( Lee Jae-Sin ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Internal Medicine
김병옥 ( Kim Byung-Wook ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Internal Medicine
허철웅 ( Huh Cheal-Wung ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Internal Medicine
김준성 ( Kim Joon-Sung ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Internal Medicine
맹이소 ( Maeng Lee-So ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Pathology

Abstract


Background/Aims: Predicting histological ulceration in early gastric cancer (EGC) during endoscopic examination is crucial for endoscopists deciding on the treatment modality. The aim of this study was to investigate the endoscopic factors that can predict histological ulcerations in EGCs.

Methods: We retrospectively analyzed patients who underwent endoscopic submucosal dissection (ESD) for EGC. Clinical features and endoscopic characteristics of EGC such as location, histological differentiation, longest diameter, tumor morphology, mucosal break, converging fold, color change, and surface irregularity were reviewed. Histological ulceration was defined based on ESD specimens.

Results: A total of 633 EGC lesions from 613 patients were included and histological ulcerations were found in 90 lesions (14.2%). Presence of converging folds, tumor morphology, and color changes on endoscopic examination were related to histological ulceration in the univariate analysis and converging folds along with color changes were statistically significant factors in the multivariate analysis. Kaplan?Meier analysis showed that patients with histological ulcerations in EGCs tended to have higher marginal recurrence rates.

Conclusions: Mucosal breaks are not equivalent to histological ulcerations. Rather, the existence of converging folds and color changes during endoscopic examination suggest histological ulcerations. Endoscopists should consider these factors when they decide the treatment modality for EGCs.

키워드

Early gastric cancer; Endoscopic submucosal dissection; Ulceration

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