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Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy

Clinical Endoscopy 2020년 53권 5호 p.555 ~ 561
김재현, 변상환, 최윤정, 권혜정, 정경원, 김성은, 박무인, 문원, 박선자,
소속 상세정보
김재현 ( Kim Jae-Hyun ) - Kosin University College of Medicine Department of Internal Medicine
변상환 ( Byun Sang-hwan ) - Kosin University College of Medicine Department of Internal Medicine
최윤정 ( Choi Youn-Jung ) - Kosin University College of Medicine Department of Internal Medicine
권혜정 ( Kwon Hye-Jung ) - Kosin University College of Medicine Department of Internal Medicine
정경원 ( Jung Kyoung-Won ) - Kosin University College of Medicine Department of Internal Medicine
김성은 ( Kim Sung-Eun ) - Kosin University College of Medicine Department of Internal Medicine
박무인 ( Park Moo-In ) - Kosin University College of Medicine Department of Internal Medicine
문원 ( Moon Won ) - Kosin University College of Medicine Department of Internal Medicine
박선자 ( Park Seun-Ja ) - Kosin University College of Medicine Department of Internal Medicine

Abstract


Background/Aims: In this study, we compared the efficacy and safety of etomidate with those of propofol or midazolam for the maintenance of sedation during endoscopy.

Methods: The study enrolled patients who underwent sedative endoscopy in our hospital and divided them into three groups. Patients in each group were administered midazolam as induction therapy and were subsequently administered either midazolam (M + M group), propofol (M + P group), or etomidate (M + E group) as maintenance medication. The primary outcome was overall cardiovascular and respiratory adverse events.

Results: In total, 105 patients who underwent sedative endoscopic examination were enrolled. The outcomes related to the procedure and sedation were not significantly different among the groups. Overall cardiovascular and respiratory adverse events were observed in 9 patients (25.7%) in the M + M group, 8 patients (23.5%) in the M + P group, and 10 patients (27.8%) in the M + E group. The logistic regression analysis revealed that etomidate use was not an independent risk factor for overall cardiovascular and respiratory adverse events.

Conclusions: The outcomes following the use of etomidate for maintenance after induction with midazolam for sedation in upper gastrointestinal endoscopy were not inferior to those following midazolam or propofol use from the perspectives of safety and efficacy.

키워드

Endoscopy; Etomidate; Midazolam; Propofol; Sedative

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