잠시만 기다려 주세요. 로딩중입니다.

Comparison of Fentanyl versus Meperidine in Combination with Midazolam for Sedative Colonoscopy in Korea

Clinical Endoscopy 2020년 53권 5호 p.562 ~ 567
Hong Gwan-Woo, 이준규, 이정현, Bong Ji-Hun, 최성훈, 조혜기, 남지형, 장동기, 강현우, 김재학, 임윤정, 고문수, 이진호,
소속 상세정보
 ( Hong Gwan-Woo ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
이준규 ( Lee Jun-Kyu ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
이정현 ( Lee Jung-Hyeon ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
 ( Bong Ji-Hun ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
최성훈 ( Choi Sung-Hun ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
조혜기 ( Cho Hye-Ki ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
남지형 ( Nam Ji-Hyung ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
장동기 ( Jang Dong-Kee ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
강현우 ( Kang Hyoun-Woo ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
김재학 ( Kim Jae-Hak ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
임윤정 ( Lim Yun-Jeong ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
고문수 ( Koh Moon-Soo ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine
이진호 ( Lee Jin-Ho ) - Dongguk University College of Medicine Dongguk University Ilsan Hospital Department of Internal Medicine

Abstract


Background/Aims: Combination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl is reportedly associated with rapid recovery, turnover rate of endoscopy room, and quality of endoscopy. We compared fentanyl with meperidine when combined with midazolam for sedative colonoscopy.

Methods: A retrospective, cross-sectional, 1:2 matching study was conducted. Induction and recovery time were compared as the primary outcomes. Moreover, cecal intubation time, withdrawal time, total procedure time of colonoscopy, paradoxical reaction, adenoma detection rate, and adverse effect of midazolam or opioids were assessed as the secondary outcomes.

Results: A total of 129 subjects (43 fentanyl vs. 86 meperidine) were included in the analysis. The fentanyl group showed significantly more rapid induction time (4.5±2.7 min vs. 7.5±4.7 min, p<0.001), but longer recovery time (59.5±25.6 min vs. 50.3±10.9 min, p=0.030) than the meperidine group. In multivariate analysis, the induction time of the fentanyl group was 3.40 min faster (p<0.001), but the recovery time was 6.38 min longer (p=0.046) than that of the meperidine group. There was no difference in withdrawal time and adenoma detection rate between the two groups.

Conclusions: The fentanyl group had more rapid sedation induction time but longer recovery time than the meperidine group.

키워드

Colonoscopy; Fentanyl; Meperidine; Midazolam; Sedation

원문 및 링크아웃 정보

등재저널 정보