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Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis

Ultrasonography 2020년 39권 2호 p.121 ~ 129
Yoo Jeong-In, 이정민, 주이진, 이동호, 윤정희, 강효진, 안수자,
소속 상세정보
 ( Yoo Jeong-In ) - Seoul National University Hospital Department of Radiology
이정민 ( Lee Jeong-Min ) - Seoul National University Hospital Department of Radiology
주이진 ( Joo I-Jin ) - Seoul National University Hospital Department of Radiology
이동호 ( Lee Dong-Ho ) - Seoul National University Hospital Department of Radiology
윤정희 ( Yoon Jeong-Hee ) - Seoul National University Hospital Department of Radiology
강효진 ( Kang Hyo-Jin ) - Seoul National University Hospital Department of Radiology
안수자 ( Ahn Su-Joa ) - Gachon University Gil Medical Center Department of Radiology

Abstract


Purpose: The purpose of this study was to evaluate the intra-observer reproducibility of ultrasound attenuation imaging (ATI) for the noninvasive assessment of hepatic steatosis in patients with suspected hepatic steatosis and the inter-observer reproducibility in asymptomatic volunteers.

Methods: This prospective study was approved by our institutional review board and informed consent was obtained from all patients. In group 1, composed of patients with suspected hepatic steatosis (n=143), one abdominal radiologist performed gray-scale ultrasonography and two sessions of ATI. In group 2, composed of healthy volunteers (n=18), three independent sessions of ATI were performed by three abdominal radiologists. The visual degree of hepatic steatosis in all study subjects was graded on a 4-point scale by two independent reviewers using gray-scale ultrasonography. Thereafter, the attenuation coefficient (AC) was correlated with the degree of hepatic steatosis using Spearman rank correlation analysis. Intra-class correlation coefficients (ICCs) were used to assess the intra-observer (group 1) and inter-observer reproducibility (group 2) of ATI measurements.

Results: For the intra-observer reproducibility of ATI, the ICC was 0.929 (95% confidence interval [CI], 0.901 to 0.949), and the coefficient of variation was 7.1%. Inter-observer reproducibility of ATI measurements showed an ICC of 0.792 (95% CI, 0.549 to 0.916). The AC showed a significant correlation with the visual grade of hepatic steatosis for both reviewers (rho, 0.780 and 0.695; P<0.001, respectively).

Conclusion: ATI showed high intra- and inter-observer reproducibility in the assessment of hepatic steatosis.

키워드

Ultrasonography; Non-alcoholic fatty liver disease; Obesity

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