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Comparison of point and 2-dimensional shear wave elastography for the evaluation of liver fibrosis

Ultrasonography 2020년 39권 3호 p.288 ~ 297
이상민, 김민정, 윤정희, 홍원주, 하홍일, 이관섭, 최지영, 이정우, 윤삼열, 한준희,
소속 상세정보
이상민 ( Lee Sang-Min ) - Hallym University Sacred Heart Hospital Department of Radiology
김민정 ( Kim Min-Jeong ) - Hallym University Sacred Heart Hospital Department of Radiology
윤정희 ( Yoon Jeong-Hee ) - Seoul National University Hospital Department of Radiology
홍원주 ( Hong Won-Ju ) - Hallym University Sacred Heart Hospital Department of Radiology
하홍일 ( Ha Hong-Il ) - Hallym University Sacred Heart Hospital Department of Radiology
이관섭 ( Lee Kwan-Seop ) - Hallym University Sacred Heart Hospital Department of Radiology
최지영 ( Choe Ji-Young ) - Hallym University Sacred Heart Hospital Department of Pathology
이정우 ( Lee Jung-Woo ) - Hallym University Sacred Heart Hospital Department of Surgery
윤삼열 ( Yoon Sam-Youl ) - Hallym University Sacred Heart Hospital Department of Surgery
한준희 ( Han Jun-Hee ) - Hallym University Department of Statistics

Abstract


Purpose: This study aimed to assess the technical performance of ElastQ Imaging compared with ElastPQ and to investigate the correlation between liver stiffness (LS) values obtained using these two techniques.

Methods: This retrospective study included 249 patients who underwent LS measurements using both ElastPQ and ElastQ Imaging equipped on the same machine. The applicability, repeatability (coefficient of variation [CV]), acquisition time, and LS values were compared using the chi-square or Wilcoxon signed-rank tests. In the development group, the correlation between the LS values obtained by the two techniques was assessed with Spearman correlation coefficients and linear regression analysis. In the validation group, the agreement between the estimated and real LS values was evaluated using a Bland-Altman plot.

Results: ElastQ Imaging had higher applicability (94.0% vs. 78.3%, P<0.001) and higher repeatability, with a lower median CV (0.127 vs. 0.164, P<0.001) than did ElastPQ. The median acquisition time of ElastQ Imaging was significantly shorter than that of ElastPQ (45.5 seconds vs. 96.5 seconds, P<0.001). The median LS value obtained using ElastQ Imaging was significantly higher than that obtained using ElastPQ (5.60 kPa vs. 5.23 kPa, P<0.001). The LS values between the two techniques exhibited a strong positive correlation (r=0.851, P<0.001) in the development group. The mean difference and 95% limits of agreement were 0.0 kPa (-3.9 to 3.9 kPa) in the validation group.

Conclusion: ElastQ Imaging may be more reliable and faster than ElastPQ, with strongly correlated LS measurements.

키워드

Liver fibrosis; Ultrasonography; Elastography; ARFI Imaging

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