잠시만 기다려 주세요. 로딩중입니다.

Impact of secondhand smoke exposure in former smokers on their subsequent risk of coronary heart disease: evidence from the population-based cohort of the Tehran Lipid and Glucose Study

Epidemiology and Health 2020년 42권 1호 p.9 ~ 9
Sadeghi Masoumeh, Daneshpour Maryam S., Khodakarim Soheila, Momenan Amir Abbas, Akbarzadeh Mahdi, Soori Hamid,
소속 상세정보
 ( Sadeghi Masoumeh ) - Shahid Beheshti University of Medical Sciences School of Public Health and Safety Department of Epidemiology
 ( Daneshpour Maryam S. ) - Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences Cellular and Molecular Endocrine Research Center
 ( Khodakarim Soheila ) - Shahid Beheshti University of Medical Sciences School of Public Health and Safety Department of Epidemiology
 ( Momenan Amir Abbas ) - Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences Prevention of Metabolic Disorders Research Center
 ( Akbarzadeh Mahdi ) - Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences Cellular and Molecular Endocrine Research Center
 ( Soori Hamid ) - Shahid Beheshti University of Medical Sciences School of Public Health and Safety Department of Epidemiology

Abstract


OBJECTIVES: Cigarette smoking is an established, strong, and modifiable risk factor for coronary heart disease (CHD). However, little research has investigated CHD risk in former smokers who continue to be exposed to others’ cigarette smoke (former & secondhand smokers).

METHODS: In the Tehran Lipid and Glucose Study, a prospective population-based cohort (n=20,069) was followed up for a median period of 14.6 years. A subset of 8,050 participants of 30 years of age and older was analyzed, with first CHD events as the study outcome. Participants were categorized as never, former, current, secondhand, and former & secondhand smokers. Data on smoking intensity (cigarette/d) were also collected. A Cox proportional hazards regression model was applied to estimate the risk of CHD, taking into account the main potential confounders.

RESULTS: The mean age of participants was 46.10 ±11.38 years, and they experienced 1,118 first CHD events (with most CHD cases in former smokers) during the follow-up period. The risk of CHD was highest in current smokers, followed in order by former & secondhand, former, and secondhand smokers (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.65 to 2.39; HR, 1.55; 95% CI, 1.15 to 2.08; HR, 1.39; 95% CI, 1.12 to 1.72; HR, 1.27; 95% CI, 1.07 to 1.51, respectively), compared to never smokers. The risk of CHD increased with smoking intensity, which has been proposed as a preferable measure of smoking, indicating a dose-response pattern.

CONCLUSIONS: The elevated risk of CHD in former & secondhand smokers was a noteworthy finding, with possible implications for health policy; however, further research is needed.

키워드

Smoking; Coronary heart disease; Cohort studies; Tehran Lipid and Glucose Study

원문 및 링크아웃 정보

 

등재저널 정보