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Effect of premature rupture of membranes on preterm labor: a case-control study in Cilegon, Indonesia

Epidemiology and Health 2020년 42권 1호 p.25 ~ 25
Sari Ita Marlita, Adisasmita Asri C., Prasetyo Sabarinah, Amelia Dwirani, Purnamasari Ratih,
소속 상세정보
 ( Sari Ita Marlita ) - Sultan Ageng Tirtayasa University Faculty of Medicine
 ( Adisasmita Asri C. ) - University of Indonesia Public Health Faculty Epidemiology Department
 ( Prasetyo Sabarinah ) - University of Indonesia Public Health Faculty Biostatistic Department
 ( Amelia Dwirani ) - Budi Kemuliaan Hospital Obstetrician
 ( Purnamasari Ratih ) - Cilegon Public Hospital

Abstract


OBJECTIVES: The global prevalence of preterm labor is approximately 11.1% of live births. However, preterm labor contributes to 75-80% of neonatal morbidity and mortality. The morbidity experienced by preterm infants may continue to influence their subsequent development, imposing physical, psychological, and economic burdens. Premature rupture of membranes (PROM) is a causal factor that may affect preterm birth. Previous studies have shown an association between PROM and preterm labor, but this association should be investigated in more diverse populations. Therefore, this study was conducted in Cilegon, Indonesia to determine the magnitude of the risk of preterm labor associated with PROM at Cilegon Hospital from July 2014 to December 2015.

METHODS: This case-control study used data from patients’ medical records. The cases were all mothers who delivered at less than 37 weeks of gestation, while the control population comprised all mothers who delivered at greater or equal to 37 weeks. The data were analyzed using logistic regression.

RESULTS: The bivariate analysis yielded an odds ratio (OR) of 2.97 (95% confidence interval [CI], 1.92 to 4.59) before controlling for covariates. The model derived through multiple regression analysis after controlling for education, history of preterm labor, and anemia resulted in an OR of 2.58 (95% CI, 1.68 to 3.98).

CONCLUSIONS: Mothers who experience PROM during pregnancy were at a 2.58 times higher risk of preterm labor after controlling for education, history of preterm labor, and anemia.

키워드

Obstetric labor; Premature birth; Rupture; Pregnant women; Case control studies; Indonesia

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