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Factors associated with in-hospital death in patients with nosocomial infections: a registry-based study using community data in western Iran

Epidemiology and Health 2020년 42권 1호 p.37 ~ 37
Khazaei Salman, Ayubi Erfan, Jenabi Ensiyeh, Bashirian Saeid, Shojaeian Masud, Tapak Leili,
소속 상세정보
 ( Khazaei Salman ) - Hamadan University of Medical Sciences Research Center for Health Sciences
 ( Ayubi Erfan ) - Zahedan University of Medical Sciences School of Medicine Department of Community Medicine
 ( Jenabi Ensiyeh ) - Hamadan University of Medical Sciences Autism Spectrum Disorders Research Center
 ( Bashirian Saeid ) - Hamadan University of Medical Sciences Social Determinants of Health Research Center
 ( Shojaeian Masud ) - Hamadan University of Medical Sciences Deputy of Health
 ( Tapak Leili ) - Hamadan University of Medical Sciences School of Public Health Department of Biostatistics

Abstract


Objectives: Determining the predictors of in-hospital death related to nosocomial infections is an essential part of efforts made in the overall health system to improve the delivery of health care to patients. Therefore, this study investigated the predictors of in-hospital death related to nosocomial infections.

Method: This registry-based, longitudinal study analyzed data on 8,895 hospital-acquired infections (HAIs) in Hamadan Province, Iran from March 2017 to December 2019. The medical records of all patients who had been admitted to the hospitals were extracted from the Iranian Nosocomial Infections Surveillance Software. The effects of the type and site of infection, as well as age group, on in-hospital death were estimated using univariate and multivariable Cox regression models.

Results: In total, 4,232 (47.8%) patients with HAIs were males, and their mean age was 48.25±26.22 years. In both sexes, most nosocomial infections involved Gram-negative bacteria and the most common site of infection was the urinary tract. Older patients had a higher risk of in-hospital death (adjusted hazard ratio [aHR], 2.26; 95% confidence interval [CI], 1.38 to 3.69 for males; aHR, 2.44; 95% CI, 1.29 to 4.62 for females). In both sexes, compared with urinary tract infections, an increased risk of in-hospital death was found for ventilator-associated events (VAEs) (by 95% for males and 93% for females) and bloodstream infections (BSIs) (by 67% for males and 82% for females).

Conclusion: We found that VAEs, BSIs, and fungal infections were independently and strongly associated with increased mortality.

키워드

Nosocomial infections; Survival; Mortality; Iran

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