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Magnetic resonance image-based tomotherapy planning for prostate cancer

Radiation Oncology Journal 2020년 38권 1호 p.52 ~ 59
정상훈, 김진성, 정윤선, Keserci Bilgin, 표홍렬, 박희철, 박원,
소속 상세정보
정상훈 ( Jung Sang-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
김진성 ( Kim Jin-Sung ) - Yonsei University College of Medicine Yonsei Cancer Center Department of Radiation Oncology
정윤선 ( Chung Yoon-Sun ) - Hanyang University Department of Nuclear Engineering
 ( Keserci Bilgin ) - Universiti Sains Malaysia School of Medical Sciences Department of Radiology
표홍렬 ( Pyo Hong-Ryull ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
박희철 ( Park Hee-Chul ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology
박원 ( Park Won ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiation Oncology

Abstract


Purpose: To evaluate and compare the feasibilities of magnetic resonance (MR) image-based planning using synthetic computed tomography (sCT) versus CT (pCT)-based planning in helical tomotherapy for prostate cancer.

Materials and Methods: A retrospective evaluation was performed in 16 patients with prostate cancer who had been treated with helical tomotherapy. MR images were acquired using a dedicated therapy sequence; sCT images were generated using magnetic resonance for calculating attenuation (MRCAT). The three-dimensional dose distribution according to sCT was recalculated using a previously optimized plan and was compared with the doses calculated using pCT.

Results: The mean planning target volume doses calculated by sCT and pCT differed by 0.65% ± 1.11% (p = 0.03). Three-dimensional gamma analysis at a 2%/2 mm dose difference/distance to agreement yielded a pass rate of 0.976 (range, 0.658 to 0.986).

Conclusion: The dose distribution results obtained using tomotherapy from MR-only simulations were in good agreement with the dose distribution results from simulation CT, with mean dose differences of less than 1% for target volume and normal organs in patients with prostate cancer.

키워드

Prostatic neoplasms; Magnetic resonance imaging; Helical tomotherapy

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