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The effect of radiotherapy on rectal cancer: a histopathological appraisal and prognostic indicators

Radiation Oncology Journal 2020년 38권 2호 p.77 ~ 83
Al Qudah Mohammad, Salmo Emil, Haboubi Najib,
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 ( Al Qudah Mohammad ) - Jordan University of Science and Technology School of Medicine Department of Pathology and Microbiology
 ( Salmo Emil ) - Royal Oldham Hospital Pennine Acute Hospitals NHS Trust Department of Histopathology
 ( Haboubi Najib ) - Spire Manchester Hospital Department of Histopathology

Abstract


The management of rectal cancer is a major undertaking. There are currently multiple treatment modalities with variable degrees of complications. Radiotherapy (RT) is one of the more frequently used modalities either on its own or more frequently with chemotherapy mostly before the definitive surgery. The outcome of RT is unpredictable. RT has its serious side effects and there are no guarantees of its usefulness in all patients. This article outlines the effect of RT on the tumor, reviews the various staging systems of responses to RT and present recent evidence of which case is less responsive to such treatments to avoid unnecessary complications.

키워드

Rectal cancer; Therapeutic oncology; Clinical pathology; MicroRNAs; Regression; Chemoradiotherapy

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