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Review of the Existing Relative Biological Effectiveness Models for Carbon Ion Beam Therapy

Progress in Medical Physics 2020년 31권 1호 p.1 ~ 7
김예진, 김진성, 조승룡,
소속 상세정보
김예진 ( Kim Ye-Jin ) - Korea Advanced Institute of Science and Technology Department of Nuclear and Quantum Engineering
김진성 ( Kim Jin-Sung ) - Yonsei University College of Medicine Yonsei Cancer Center Department of Radiation Oncology
조승룡 ( Cho Seung-Ryong ) - Korea Advanced Institute of Science and Technology Department of Nuclear and Quantum Engineering

Abstract


Hadron therapy, such as carbon and helium ions, is increasingly coming to the fore for the treatment of cancers. Such hadron therapy has several advantages over conventional radiotherapy using photons and electrons physically and clinically. These advantages are due to the different physical and biological characteristics of heavy ions including high linear energy transfer and Bragg peak, which lead to the reduced exit dose, lower normal tissue complication probability and the increased relative biological effectiveness (RBE). Despite the promising prospects on the carbon ion radiation therapy, it is in dispute with which bio-mathematical models to calculate the carbon ion RBE. The two most widely used models are local effect model and microdosimetric kinetic model, which are actively utilized in Europe and Japan respectively. Such selection on the RBE model is a crucial issue in that the dose prescription for planning differs according to the models. In this study, we aim to (i) introduce the concept of RBE, (ii) clarify the determinants of RBE, and (iii) compare the existing RBE models for carbon ion therapy.

키워드

Carbon ion radiotherapy; Relative biological effectiveness; Local effect model; Microdosimetric kinetic model

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